Human T-cell leukemia virus type I at age 25: a progress report.
نویسندگان
چکیده
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.
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عنوان ژورنال:
- Cancer research
دوره 65 11 شماره
صفحات -
تاریخ انتشار 2005